RU486 Mitigates Hippocampal Pathology Following Status Epilepticus
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چکیده
منابع مشابه
RU486 Mitigates Hippocampal Pathology Following Status Epilepticus
Status epilepticus (SE) induces rapid hyper-activation of the hypothalamo-pituitary-adrenocortical (HPA) axis. HPA axis hyperactivity results in excess exposure to high levels of circulating glucocorticoids, which are associated with neurotoxicity and depression-like behavior. These observations have led to the hypothesis that HPA axis dysfunction may exacerbate SE-induced brain injury. To test...
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PURPOSE To define the neuropathological findings of pulvinar degeneration seen in long duration status epilepticus. METHODS We review the clinical, radiologic, neurophysiologic, investigational and neuropathological findings on a 27 year old woman who died after 162 days of prolonged refractory status epilepticus. RESULTS Continuous EEG monitoring confirmed recurrent uncontrolled seizure ac...
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Status epilepticus (SE) is a severe neurological condition that can result in brain damage. In animals, SE is associated with cell loss and aberrant synaptogenesis. These pathological processes appear to be activity-dependent and may continue after the SE has ended. We postulated that suppression of electrical activity following SE at the site of the epileptic focus will reduce seizure-induced ...
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ژورنال
عنوان ژورنال: Frontiers in Neurology
سال: 2016
ISSN: 1664-2295
DOI: 10.3389/fneur.2016.00214